Experimental Pulmonary Reimplantation

Pulmonary reimplantation response in single-lung transplantation.

We studied the characteristics of the pulmonary reimplantation response (PRR) in single-lung transplantation (SLT), and detailed the occurrence, evolution, prognosis and risk factors of this complication. Forty single-lung transplant recipients were studied. Twenty four patients developed hypoxaemia and allograft infiltrates consistent with the PRR. In 40% of the cases hypoxaemia was severe, pr...

Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response.

BACKGROUND Although the development of noncardiogenic pulmonary edema or pulmonary reimplantation response (PRR) after lung transplantation has been well described, the incidence has not been established and the relationship of PRR to clinical risk factors has not been analyzed. STUDY OBJECTIVES (1) To describe the incidence of PRR in lung transplant recipients, (2) to identify the predictors...

Long-term survival of dogs after experimental pulmonary reimplantation and staged contralateral pneumonectomy.

Sixteen dogs which survived left pulmonary reimplantation were subjected to staged contralateral pneumonectomy. Complete excision of the right lung was achieved in nine of these animals. There were three long-term survivors, of which two lived for more than three years on the singl$e reimplanted lung. Stenosis of the pulmonary veins at the level of the atrial anastomosis was the commonest post-...

Pulmonary mechanics and surfactant measurement in canine lungs following reimplantation.

Glutathione decreases the pulmonary reimplantation response in canine lung autotransplants.

The pulmonary reimplantation response (PRR) is a form of membrane permeability pulmonary edema occurring in lung transplants. The severity of the PRR reflects the quality and duration of lung graft preservation. Free radicals formed during ischemia with reperfusion in the autotransplanted dog lung may play a role in producing PRR. We hypothesized that the addition of reduced glutathione (GSH) t...